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desvenlafaxine will raise the amount or effect of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by around 50%; no dosage adjustment essential with desvenlafaxine doses 7 consecutive times right a